Deprivation changes initial affective value of sodium saccharin

Reproductive toxicology. Sodium saccharin.

The Toll-like receptor 4 (TLR4) is a class I transmembrane receptor expressed on the surface of immune system cells. TLR4 is activated by exposure to lipopolysaccharides derived from the outer membrane of Gram negative bacteria and forms part of the innate immune response in mammals. Like other class 1 receptors, TLR4 is activated by ligand induced dimerization, and recent studies suggest that ...

Evidence on the Carcinogenicity of Sodium Saccharin

Affective Consequences of Sleep Deprivation

Surprisingly little is known about the effects of sleep deprivation on affective processes. Although clinical evidence and introspection suggest that emotional function is sensitive to sleep loss, there are only three published studies that have experimentally manipulated both stress and emotion in a single experiment, the earliest of which was published in 2007. This dissertation presents find...

Development of alcohol deprivation effect in rats: lack of correlation with saccharin drinking and locomotor activity.

The present study addressed the relationship between the parameters of saccharin drinking behaviour and locomotor activity in an open field environment and long-term alcohol self-administration. In a 22-day initiation phase, male Wistar rats were presented with increasing concentrations of ethanol (2-8%, v/v) in a choice with water. The rats were then given the choice between water and two etha...

Value Crisis: Affective Organization of Personal Meanings